Abstract

Review Article

Extremely large hemangioma of the liver: Safety of the expectant management

Subhi Mansour, Sharbel Khouri, Maisa Andraous and Safi Khuri*

Published: 06 September, 2019 | Volume 3 - Issue 2 | Pages: 061-064

Hemangiomas are known as congenital vascular malformations that can affect almost any organ or tissue, with the liver being the most common intra-abdominal organ to be involved. It is well known that hemangiomas are the most common benign tumours of the liver, and develop in about 4-20% of people, mainly young adult females. Recently, due to the dramatic rise in the use of imaging studies for different purposes, a parallel increase in the incidence of these tumours has been noticed. Most liver hemangiomas are small (less than 4cm in diameter), asymptomatic and found incidentally during abdominal operation for other indication or on radiologic studies. Giant liver hemangioma is defined as hemangioma with a diameter of more than 5cm. This unique and uncommon type of haemangioma usually poses therapeutic challenges for the treating physician, especially hepatic surgeons, due to the unclear natural history, and due to the risk of life threatening complications is yet to be established. While it is already proved by several studies that conservative management of giant hepatic hemangioma is safe, it is not known whether observation of the extremely large hepatic hemangioma (tumours larger than 10cm) is safe as well.

The aim of this article is to review the English literature to find out if conservative management of the extremely giant liver hemangioma is safe and can be recommended.

Read Full Article HTML DOI: 10.29328/journal.ascr.1001036 Cite this Article Read Full Article PDF

Keywords:

Extremely large hepatic hemangioma; Conservative management

References

  1. Maestroni U, Dinale F, Frattini A, Cortellini P. Ureteral hemangioma: A clinical case report. Acta Biomed. 2005; 76: 115-117. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16350557
  2. Tait N, Richardson AJ, Muguti G, Little JM. Hepatic cavernous haemangioma: A 10 year review. Aust N Z J Surg. 1992; 62: 521-524. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/1610320
  3. Choi BY, Nguyen MH. The diagnosis and management of benign hepatic tumors. J Clin Gastroenterol. 2005; 39: 401-412. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15815209
  4. Lise M, Feltrin G, Da Pian PP, Miotto D, Pilati PL, et al. Giant cavernous hemangioma: diagnosis and surgical strategies. World J Surg. 1992; 16: 516-20. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/1589990
  5. Bioulac-Sage P, Laumonier H, Laurent C, Blanc JF, Balabaud C. Benign and malignant vascular tumors of the liver in adults. Semin Liver Dis. 2008; 28: 302-314. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/18814083
  6. Ketchum WA, Lin-Hurtubise KM, Ochmanek E, Ishihara K, Rice RD. Management of Symptomatic Hepatic "Mega" Hemangioma. Hawaii J Med Public Health. 2019; 78: 128-131. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30972235
  7. Zhuang BW, Li W, Chen ZF, Cao CJ, Xie XY, et al. Multiple cavernous hemangiomas of the lung and liver mimicking metastasis: A case report and literature review. Medicine (Baltimore). 2018; 97: e13509. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30572451
  8. Farges O, Daradkeh S, Bismuth H. Cavernous hemangiomas of the liver: are there any indications for resection? World J Surg. 1995; 19: 19-24. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/7740805
  9. Okano H, Shiraki K, Inoue H, Ito T, Yamanaka T, et al. Natural course of cavernous hepatic hemangioma. Oncol Rep. 2001; 8: 411-414. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/11182065
  10. Pietrabissa A, Giulianotti P, Campatelli A, Di Candio G, Farina F, et al. Management and follow-up of 78 giant haemangiomas of the liver. Br J Surg. 1996; 83: 915-918. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8813773
  11. Yoon SS, Charny CK, Fong Y, Jarnagin WR, Schwartz LH, et al. Diagnosis, management, and outcomes of 115 patients with hepatic hemangioma. J Am Coll Surg. 2003; 197: 392-402. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12946794
  12. Erdogan GD, Busch OR, Van Delden OM, Bennink RJ, ten Kate FJ, et al. Management of liver hemangiomas according to size and symptoms. J Gastroenterol Hepatol. 2007; 22: 1953-1958. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17914976
  13. Hoekstra LT, Bieze M, Erdogan D, Roelofs JJ, Beuers UH, et al. Management of giant liver hemangiomas: An update. Expert Rev Gastroenterol Hepatol. 2013; 7: 263-268. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23445235
  14. Schnelldorfer T, Ware AL, Smoot R, Schleck CD, Harmsen WS, et al. Management of giant hemangioma of the liver: resection versus observation. J Am Coll Surg. 2010; 211: 724-730. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20980175
  15. Yedibela S, Alibek S, Muller V, Aydin U, Langheinrich M, et al. Management of Hemangioma of the Liver: Surgical Therapy or Observation? World J Surg. 2013; 37: 1303-1312. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23354918
  16. Herman P, Costa MLV, Machado MAC, Pugliese V, D'Albuquerque LAC, et al. Management of Hepatic Hemangiomas: A 14-Year Experience. J Gastrointest Surg. 2005; 9: 853-859. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15985244
  17. Marcello D, Gregor S, Angelo D, Karl O. The risk of spontaneous rupture of liver hemangiomas: A critical review of the literature. J Hepatobiliary Pancreat Sci. 2011; 18: 797-805. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21796406
  18. Giuliante F, Ardito F, Vellone M, Giordano M, Ranucci G, et al. Reappraisal of surgical indications and approach for liver hemangioma: single-center experience on 74 patients. Am J Surg. 2011; 201: 741-748. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20937504
  19. Zhang W, Huang ZY, Ke CS, Wu C, Zhang ZW, et al. Surgical Treatment of Giant Liver Hemangioma Larger Than 10?cm: A Single Center's Experience with 86 Patients. Medicine (Baltimore). 2015; 94: e1420. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26313792
  20. Bajenaru N, Balaban V, Savulescu F, Campeanu I, Patrascu T. Hepatic hemangioma- review. J Med Life. 2015; 8: 4-11. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26361504

Figures:

Figure 1

Figure 1

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More