GELS as Pharmaceutical Form in Hospital Galenic Practice: Chemico-physical and Pharmaceutical Aspects
Article Sidebar
Main Article Content
Abstract
This work aims to describe the chemical-physical properties of various GELS used as galenic forms in hospital pharmacy practice. After an overview of the excipients and method used three preparations are reported. LAT GEL is used as an anesthetic in an emergency (pediatry ) in treating little Traumatic lacerations of the skin and scalp, calcium gel is used as an antidote for fluoride acid burns, and Lidocaine viscose 2% oral gel is used in some pathological conditions like severe esophagitis in onco - hematological patients after radiotherapy or chemotherapy. The galenic role in the situation of some drug shortages was also analyzed.
Article Details
Copyright (c) 2025 Luisetto M, et al.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Benelli E, Zanon D, Bressan S, Facchina G, Vecchiato K, Pusceddu S, et al. Anesthetic efficacy of LAT gel for superficial wounds in a pediatric population. Already done?!. Doctor and Child. 2013;16(5). Available from: https://www.medicoebambino.com/?id=RIC1305_10.html
Zanon D, Volpato C, Addobbati R, Loiacono S, Maestro A. Stability of a novel Lidocaine, Adrenaline, and Tetracaine sterile thermosensitive gel: A ready-to-use formulation. Eur J Pharm Sci. 2019;136:104962. Available from: https://doi.org/10.1016/j.ejps.2019.104962
SIFO Galenic Code. 2010. Available from: https://www.sifoweb.it/biblioteca-sifo/altre-edizioni/4275-codice-di-galenica-sifo.html
DM 18 November 2003 Italy; Procedure for preparation of magistral and officinal. DM Salute 18.11.2003 (Simplified NBP (NORME DI BUONA PREPARAZIONE) rules).
NBP official pharmacopeia. Italy. Available from: https://www.iss.it/web/iss-en/official-pharmacopoeia-of-the-italian-republic
Sheskey PJ, Hancock BC, Moss GP, Goldfarb DJ, editors. Handbook of Pharmaceutical Excipients. 9th ed. London: Pharmaceutical Press; 2022. ISBN 9780857113757.
Nicoletti G, Pellegatta T, Scevola S. Current affairs on the electrical safety of equipment used in surgery and interventional medicine. G Ital Med Lav Ergon. 2013;35(3):176-82. Italian. Available from: https://pubmed.ncbi.nlm.nih.gov/24734325/
Donald C, White A. LAT gel topical anesthetic for pediatric wounds. 2016. Available from: https://rightdecisions.scot.nhs.uk/nhs-tayside-ed-guidance/paediatrics/paediatric-analgesia/lat-gel/lat-gel-topical-anaesthetic-for-paediatric-wounds/
Rowe RC, Sheskey PJ, Quinn ME, editors. Handbook of Pharmaceutical Excipients. 6th ed. London; Chicago; Washington, DC: Pharmaceutical Press; American Pharmacists Association; 2009. Available from: https://adiyugatama.wordpress.com/wp-content/uploads/2012/03/handbook-of-pharmaceutical-excipients-6th-ed.pdf
Malkin AY, Derkach SR, Kulichikhin VG. Rheology of Gels and Yielding Liquids. Gels. 2023;9(9):715. Available from: https://doi.org/10.3390/gels9090715
Gels. Available from: https://thefactfactor.com/facts/pure_science/chemistry/physical-chemistry/gels/11922/
Capellmann R, Schmiedeberg M. Insights into gels. Available from: https://phys.org/news/2016-07-insights-gels.html
Li X, Fu M, Hu J. Preparation and Performance Evaluation of Temperature-Resistant and Salt-Resistant Gels. Gels. 2024;10(5):337. Available from: https://doi.org/10.3390/gels10050337
Ernst AA, Marvez-Valls E, Nick TG, Mills T, Minvielle L, Houry D. Topical lidocaine adrenaline tetracaine (LAT gel) versus injectable buffered lidocaine for local anesthesia in laceration repair. West J Med. 1997;167(2):79-81. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC1304430/
Vandamme E, Lemoyne S, van der Gucht A, de Cock P, van de Voorde P. LAT gel for laceration repair in the emergency department: not only for children? Eur J Emerg Med. 2017;24(1):55-59. Available from: https://doi.org/10.1097/mej.0000000000000298
Chick LR, Borah G. Calcium carbonate gel therapy for hydrofluoric acid burns of the hand. Plast Reconstr Surg. 1990;86(5):935-40. Available from: https://doi.org/10.1097/00006534-199011000-00016
Yamashita S, Sato S, Kakiuchi Y, Miyabe M, Yamaguchi H. Lidocaine toxicity during frequent viscous lidocaine use for painful tongue ulcer. J Pain Symptom Manage. 2002;24(5):543-5. Available from: https://doi.org/10.1016/s0885-3924(02)00498-0
Public Health Advisory: Life-Threatening Side Effects with the Use of Skin Products Containing Numbing Ingredients for Cosmetic Procedures. 1/2009: For current information on this issue. 2/6/2007. Available from: https://ohsonline.com/articles/2009/01/19/19-fda-issues-public-health-advisory-alert-on-skin-numbing-products.aspx?m=1
Elad S, Raber-Durlacher JE, Brennan MT, Saunders DP, Mank AP, Zadik Y, et al. Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT). Support Care Cancer. 2015;23(1):223-36. Available from: https://doi.org/10.1007/s00520-014-2378-x