New era of liver transplantation for HIV-HCV Co-infected patients: A case report

Main Article Content

Konstantinos A Zorbas
Sunil S Karhadkar
Kwan N Lau
Andreas Karachristos
Antonio Di Carlo

Abstract

Morbidity and mortality of HIV-infected patients have been improved over the last decades with the advent of combined antiretroviral therapy. As a result, other comorbidities such as chronic kidney and chronic liver diseases have emerged in the HIV population. A considerable percentage of end-stage liver disease (ESLD) in HIV population is attributed to hepatitis C co-infection and reactivation, and a growing need for solid organ transplantation has emerged among those patients. On the other hand, several studies on liver transplantations of patients co-infected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) have shown discouraging results both in patient and graft survival rates. As a result, HIV-HCV co-infection has been considered a relative contraindication for liver transplantation. Thankfully, new drugs for HCV treatment have been discovered, acting direct on viral replication of HCV and they have changed the whole clinical course of HCV/HIV co-infected liver transplant recipients. Our case illustrates the long-term efficacy and safety of the new combination of Sofosbuvir/Ledipasvir in HCV/HIV co-infected liver transplant recipients.

Article Details

Zorbas, K. A., Karhadkar, S. S., Lau, K. N., Karachristos, A., & Carlo, A. D. (2017). New era of liver transplantation for HIV-HCV Co-infected patients: A case report. Archives of Surgery and Clinical Research, 1(1), 072–076. https://doi.org/10.29328/journal.ascr.1001012
Case Reports

Copyright (c) 2017 Zorbas KA, et al.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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